Where Does The Gunpowder Go To At Poptropica

amino acids in the diet help fertility

The estrogen receptor in the liver is sensitive to ingested protein in the diet, ensuring that pregnancy occurs only with adequate nutrition

Thinking about a important organ for fertility, in general our thinking nothing is in the liver. Yet, a study reported in the February issue of Cell Metabolism, conducted by a study group coordinated by Adriana Maggi, director of the Center of Excellence on Neurodegenerative Diseases University of Milan, not only establishes a definitive physiological relevance estrogen receptor in the liver but shows that the amino acids in the diet act directly on this receptor, activating it, and therefore play a very important for fertility.

has long been known that the estrogen receptor was expressed in the liver, but none so far had studied the role of this molecule. The team from the University of Milan has been working on an animal model in which the activity of the estrogen receptor could be investigated with non-invasive methods in animals living image. From the beginning the model indicated that the estrogen receptor in the liver proved more active than in any other body, including organs directly related to reproduction.

Furthermore, by putting the mice in caloric restriction has been detected a loss of hepatic estrogen receptor activity and decreased hepatic production of the hormone IGF-1 (or somatotropin) and inadequate for the normal progression of cycle and the preparation of the uterine wall implant fertilized egg. Dando after caloric restriction in mice more protein, but not carbohydrates or fats, the production of IGF-1 was restored and the rats returned to having a fertile cycle.

The assumption made by the research group is that the estrogen receptor in the liver acts as a sensor energy metabolism, ensuring that pregnancy occurs only in people who have adequate nutrition. The findings may help explain the mechanism that regulates puberty, some forms of amenorrhea and perhaps even fertility problems linked to obesity. As has long been known the relationship between anorexia and infertility, other forms of infertility, the cause of today is not correctly diagnosed, may in fact be linked to diets too rich in carbohydrates and fats

Maggi Comment: "This study has important implications for the explanation of some forms of infertility due to lower-protein diets and opens new perspectives for understanding of metabolic changes that occur with menopause or after pregnancy (such as diabetes postpartum). In addition, confirmation of the centrality of the hepatic estrogen receptor may help the search for new drugs capable of modulating the activity of this molecule only in the liver, allowing for new and more appropriate therapies for menopause. "
Editorial MolecularLab.it (02/10/2011)